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FLASH GENE
Symbol TCN1 contributors: - updated : 16-03-2006
HGNC name transcobalamin I (vitamin B12 binding protein, R binder family)
HGNC id 11652
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland    
 stomach   highly
Endocrinepancreas   moderately
 parathyroid   moderately
Reproductivefemale systembreastmammary gland moderately
 male systemprostate  moderately
Respiratoryrespiratory tractlarynx  highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticneutrophil
cell lineage
cell lines
fluid/secretion milk, saliva, tears, bile, plasma
at STAGE
physiological period
Text later stages of myeloid development
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
a signal peptide
conjugated GlycoP
isoforms Precursor a signal peptide from the 1st to the 23th aa
HOMOLOGY
Homologene
FAMILY
  • vitamin B12-binding protein family
  • eukaryotic cobalamin transport protein family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    text secreted, secondary granules
    basic FUNCTION facilitating the transport of cobalamin into cells
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS exocytosis transport , cellular trafficking transport
    text cobalamin transport
    PATHWAY
    metabolism
    signaling
    a component major constituent ofsecondary granules in neutrophils
    INTERACTION
    DNA
    RNA
    small molecule metal binding,
    ion Co2+
    protein
    cell & other vitamin B12
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS