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FLASH GENE
Symbol RPSA contributors: mct - updated : 02-04-2014
HGNC name ribosomal protein SA
HGNC id 6505
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • region between AAs 236-262 is required for binding to 40S ribosomal subunits
  • a eukaryote-specific C-terminal domain (CTD) that is responsible in RPSA for the binding of laminin as well as prions and several viruses , and ability of RPSA to regulate viability is associated with its C-terminal 75 AAs but this function is distinct from its role in cell proliferation, independent of its ribosomal functions, and may be regulated by a nonnuclear localization
  • isoforms Precursor precursor of the cell-surface laminin receptor, LAMR (RPSA)
    HOMOLOGY
    interspecies homolog to murine Lamr1
    Homologene
    FAMILY ribosomal protein S2P family
    CATEGORY adhesion , signaling , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,cytosolic,ribosome
    intracellular,nucleus
    basic FUNCTION
  • involved in translational machinery
  • playing a major role in tumor aggressiveness and metastasis
  • promotes CNF1-expressing E. coli K1 internalization of human brain microvascular endothelial cells
  • multifunctional protein, acting as an extracellular receptor, localizing to the nucleus, and playing roles in rRNA processing and ribosome assembly
  • non integrin cell surface receptor for the extracellular matrix whose expression is increased in neoplastic cells and directly correlates with an enhanced invasive and metastatic potential
  • role in cancer and infection diseases
  • functions as a cancer-specific death receptor
  • essential role for RPSA in human spleen development
  • CELLULAR PROCESS protein, translation/synthesis
    protein, translation regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component component of the small subunit of the ribosome
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • PRP (prion protein)-receptor for cellular PRP on the surface of cells
  • CTSB (increasing the laminin degradation rate and releasing motility fragments)
  • targeting PPYR1 (LAMR1 is a PPP1R16B-dependent PPYR1 substrate)
  • upon TCR plus integrin costimulation, SH2D2A associates with RPSA and mediates T lymphocyte migration
  • molecular interaction of PEA15 with RPSA (PEA15 ability to induce cell responses to ECM-derived signals through interaction with RPSA may be of crucial importance for tumour cell survival in a poor microenvironment, thus favouring the metastatic spread and colonization)
  • cell & other associating with the ribosome
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ICAS
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    higher in colon carcinoma tissue, urothelial tumors and lung cancer cell line than their normal counterparts
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    PDE5A inhibitors could be used to elevate cGMP levels to induce RPSA-mediated, cancer-specific cell death
    ANIMAL & CELL MODELS