basic FUNCTION
| 17 beta-hydroxysteroid dehydrogenase, catalyzing preferentially the oxidation of estradiol |
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involded in the degradation of very long chain fatty acids (VLCFA, branched chain fatty acids and shortening cholesterol for bile acid formation) |
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multifunctional peroxisomal enzyme involved in fatty acid beta-oxidation and steroid metabolism (Pierce 2010) |
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has multiple tasks in the adult brain, including the maintenance of Purkinje cells and the prevention of neuroinflammation but this is not mediated by its activity in oligodendrocytes nor by its role in very long chain fatty acid degradation |
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HSD17B4 plays an important role in aggravated hepatocellular carcinoma (HCC) progression |
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crosstalk between acetylation and chaperone-mediated autophagy (CMA) degradation in HSD17B4 regulation, and a critical role of the regulation in the malignant progression of breast cancer |