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FLASH GENE
Symbol HSD17B4 contributors: /mct - updated : 18-05-2018
HGNC name hydroxysteroid (17-beta) dehydrogenase 4
HGNC id 5213
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver   highly
Nervousbrain   lowly
Reproductivefemale systemuterus  lowly
 male systemtestis   
 male systemprostate   
Respiratorylung   lowly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • three functional domains: an N-terminal 3-hydroxyacyl-CoA dehydrogenase domain, short chain alcohol dehydrogenase with dehydrogenase activity
  • a central 2-enoyl-CoA hydratase domain
  • C- terminus responsable for sterol transport, a C-terminal sterol carrier protein 2-like domain (SCP-2L) (Pierce 2010)
  • HOMOLOGY
    Homologene
    FAMILY
  • short-chain dehydrogenases/reductases (SDR) family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    basic FUNCTION
  • 17 beta-hydroxysteroid dehydrogenase, catalyzing preferentially the oxidation of estradiol
  • involded in the degradation of very long chain fatty acids (VLCFA, branched chain fatty acids and shortening cholesterol for bile acid formation)
  • multifunctional peroxisomal enzyme involved in fatty acid beta-oxidation and steroid metabolism (Pierce 2010)
  • has multiple tasks in the adult brain, including the maintenance of Purkinje cells and the prevention of neuroinflammation but this is not mediated by its activity in oligodendrocytes nor by its role in very long chain fatty acid degradation
  • HSD17B4 plays an important role in aggravated hepatocellular carcinoma (HCC) progression
  • crosstalk between acetylation and chaperone-mediated autophagy (CMA) degradation in HSD17B4 regulation, and a critical role of the regulation in the malignant progression of breast cancer
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS reproduction/sex
    PATHWAY
    metabolism energetic , lipid/lipoprotein
    signaling hormonal
    peroxisomal fatty acid beta-oxidation (second and third steps)
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) ZWS4 , GDXD
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    of HSD17B4 exerted tumor suppressive function in adrenocortical carcinoma and was not related to hormone excess
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerreproductivebreast
    PDGFRA, HSD17B4 and HMGB2 are potential therapeutic targets in polycystic ovarian syndrome and breast cancer
    cancerdigestiveliver
    novel therapeutic target for hepatocellular carcinoma
    ANIMAL & CELL MODELS