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FLASH GENE
Symbol NT5E contributors: mct/shn - updated : 12-06-2013
HGNC name 5'-nucleotidase, ecto (CD73)
HGNC id 8021
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Endocrinethyroid   highly
Respiratoryrespiratory tracttrachea  highly
Skin/Tegumentskin   highly
Urinarykidney    
Visualeye    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticleukocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta, retina
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
conjugated GlycoP
mono polymer homomer , dimer
HOMOLOGY
interspecies ortholog to Nt5e, Mus musculus
ortholog to nt5e, Danio rerio
ortholog to Nt5e, Rattus norvegicus
ortholog to NT5E, Pan troglodytes
Homologene
FAMILY 5'-nucleotidase family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     plasma membrane
text
  • bounds by a glycosyl phosphatidyl inositol linkage to the external face of the plasma membrane
  • expressed on normal and neoplastic glial plasma membranes (Ludwig et al, 1999)
  • basic FUNCTION
  • cell surface enzyme of the purine catabolic pathway that catalyzes the breakdown of AMP to adenosine
  • hydrolyzing extracellular nucleotides into membrane permeable nucleosides
  • may facilitate the adhesion, migration and invasion of human breast cancer cells through its enzyme activity of generating adenosine
  • required for the efficient entry of lymphocytes into the CNS during experimental autoimmune encephalomyelitis development
  • novel and specific receptor for tenascin C and the interaction between these proteins may influence cell adhesion and migration and also lead to decreased generation of local adenosine (Sadej 2008)
  • a signalling pathway metabolite in the immune response of lymphocytes
  • a cell surface marker of cone/rod common precursors and mature rod cells genetically localized between Nrl and Crx (Koso 2009)
  • extracellular adenosine, generated in tandem by ecto-enzymes ENTPD1 and NT5E, promotes dermal fibrogenesis
  • ENTPD1, NT5E are two ectonucleotidases that cooperate in the generation of extracellular adenosine through ATP hydrolysis, thus tilting the balance towards immunosuppressive microenvironments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text catalyzes the conversion at neutral pH of purine 5-prime mononucleotides to nucleosides
    PATHWAY
    metabolism purine/pyrimidine
    signaling
    nucleotide
    a component
  • glycoprotein constituent of membrane (Pi linked)
  • component of multiresistance machinery, the transcription of which is activated under selective pressure of the immune system (Ludwig et al, 1999)
  • INTERACTION
    DNA
    RNA
    small molecule cofactor,
    zinc
    protein
  • intracellular filamentous actin and the extracellular matrix proteins laminin and fibronectin (Ludwig et al, 1999)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in melanoma with with a highly invasive phenotype
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    dermatologyskin 
    biochemical or biological inhibitors of ENTPD1 and/or NT5E may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma
    ANIMAL & CELL MODELS
  • ecto-5'-nucleotidase/CD73-deficient mice have a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow (Castrop et al, 2004)