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FLASH GENE
Symbol ALDH7A1 contributors: mct/npt - updated : 09-04-2008
HGNC name aldehyde dehydrogenase 7 family, member A1
HGNC id 877
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Hearing/Equilibriumearinnercochlea highly
Reproductivefemale systemovary   
 female systemuteruscervix highly
Respiratoryrespiratory tractlarynx  highly
Urinarykidney    
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
mono polymer homomer , dimer
HOMOLOGY
interspecies homolog to green pea
Homologene
FAMILY
  • aldehyde dehydrogenase family
  • CATEGORY enzyme , regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria
    basic FUNCTION
  • hypothetical aldehyde dehydrogenase regulating osmotic pressure
  • playing a major role in the detoxification of aldehydes generated by alcohol metabolism and lipid peroxidation
  • degrades and detoxifies acetaldehyde generated by alcohol metabolism (Guo 2010)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling sensory transduction/hearing
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) EPD
    Susceptibility to low-trauma osteoporotic fractures (OF)
    Variant & Polymorphism SNP SNP, rs13182402 within the ALDH7A1 gene on chromosome 5q31, was strongly associated with OF (Guo 2010)
    Candidate gene potential candidate gene contributing to the risk of osteoporosis (Guo 2010)
    Marker
    Therapy target
    ANIMAL & CELL MODELS