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FLASH GENE
Symbol ATF6B contributors: mct - updated : 12-10-2011
HGNC name activating transcription factor 6 beta
HGNC id 2349
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • basic leucine zipper (bZIP) protein
  • five evolutionarily conserved N-linked glycosylation sites
    • conjugated GlycoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endoplasmic reticulum
    intracellular,nucleus
    basic FUNCTION
  • endogenous ATF6B moderated ER stress-response gene induction
  • may serve as a transcriptional repressor functioning in part to regulate the strength and duration of ATF6-mediated ER stress-response gene activation during the ER stress response
  • ATF6 and ATF6B, are cleaved during the ER stress response (ERSR)
  • relative levels of ATF6 and ATF6B, may contribute to regulating the strength and duration of ATF6-dependent ERSR gene induction and cell viability
  • key transcriptional repressor of ATF6, which contribute to regulating the strength and duration of ATF6-dependent ER stress response (ERSR) gene induction
  • unglycosylated ATF6B may directly facilitate the expression of ERSR genes by losing its repressor function to ATF6
    • CELLULAR PROCESS nucleotide, transcription
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding to cAMP response element
    RNA
    small molecule
    protein
  • cellular protein that interacts with the NS4B protein of hepatitis C virus
  • host cellular target of the Toxoplasma gondii virulence factor ROP18
    • cell & other
    REGULATION
    activated by activated in response to ER stress
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS