SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytoskeleton,microtubule,centrosome
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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| intracellular,nucleus
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text
| the N-terminus interacts with microtubules and a separate carboxy-terminal domain is required for centrosomal targeting |
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associated with the cytoskeleton, microtubules, centrosomes and the mitotic spindle |
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found in the cell nucleus, on interphase microtubules, mitotic spindles, centrosomes, and within mitochondria |
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distributed in both the cytoplasm and nucleus |
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localized to the microtubule cytoskeleton and along mitotic spindles |
basic FUNCTION
| cell surface receptor for hyaluronan, and a microtubule-associated intracellular hyaluronan binding protein involved in signal transduction via Src tyrosine kinase family |
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functioning in the maintenance of spindle integrity |
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playing an important role in maintenance of embryonic stem cells pluripotency, viability, and cell cycle control |
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playing a role already in S phase |
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oncogenic protein implicated in the progression of many cancers, including breast, acute myeloid leukemia, multiple myeloma, gastric, and prostate cancers |
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required for regulating stability of interphase and mitotic microtubules and this function resided in the C-terminal 728LKDENSQLKSEVSKL742 microtubule-binding site |
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control the structure of interphase and mitotic spindle microtubules and these effects are driven by MEK1/ERK1/2 kinase activity |
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has a predominant role in the cell cycle in immortalized cells (HCF) |
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ARPC5 and HMMR, in addition to PRKCA, were required for migration of neointimal smooth muscle cells |
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centrosomal protein that contributes to the stability of the mitotic spindle |
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may play a key role in the osteoblastic differentiation process |
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ANKRD26, TRIO, GPS2 and HMMR are novel and important regulators of adipogenesis |
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cell-surface receptor for hyaluronan that regulates embryonic stem cell pluripotency and differentiation |
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required to maintain pluripotency and its dominant mechanism of action is through the modulation of signal transduction pathways at microtubules |