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FLASH GENE

Symbol

MEP1A

contributors: - updated : 27-10-2005

HGNC name	meprin A, alpha (PABA peptide hydrolase)
HGNC id	7015

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         intestine large intestine colon     Urinary kidney

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Blood / Hematopoietic         Epithelial         Membrane mucous lamina propria intestine villi

cells

System Cell Pubmed Species Stage Rna symbol Blood/Hematopoietic leukocyte

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a signal peptide,
	a propeptide,
	a protease domain containing an astacin signature,
	a meprin A-5 protein tyrosine phosphatase mu(MAM),
	a meprin and TRAF homology (MATH)domain,
	an after MATH (AM) domain,
	an EGF like domain,
	a putative transmembrane segment (1TM)
	a short cytoplasmic tail

conjugated

GlycoP

mono polymer

homomer , heteromer , oligo

HOMOLOGY

Homologene

FAMILY

astacin family of zinc metalloendopeptidases

CATEGORY

enzyme

SUBCELLULAR LOCALIZATION	extracellular
	plasma membrane
text	secreted forms

basic FUNCTION

hydrolysing basement membrane components such as collagen IV, nidogen-1 and fibronectin

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

associating with MEP1B

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS