basic FUNCTION
| lymphocyte tryptase |
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despite a more restricted cellular expression pattern, GzmK seems to participate in immune responses against several viruses |
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directly processes BID to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death |
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serine protease stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells |
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cleaved the microtubule network protein beta-tubulin after two distinct Arg residues, and potentially displays a unique function by cleaving its own specific substrates |
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may exert a critical role in NK cell-mediated tumor clearance |
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key component of T-killer (Tc) cells believed to mediate pro-apoptotic activities |
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extracellular GZMK is capable of activating F2R and inducing fibroblast cytokine secretion and proliferation |