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FLASH GENE
Symbol GZMK contributors: mct - updated : 11-05-2012
HGNC name granzyme K (granzyme 3; tryptase II)
HGNC id 4711
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immuneactivated B lymphocyte
Lymphoid/Immunenatural killer Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • lymphocyte tryptase
  • despite a more restricted cellular expression pattern, GzmK seems to participate in immune responses against several viruses
  • directly processes BID to release cytochrome c and endonuclease G leading to mitochondria-dependent cell death
  • serine protease stored in cytolytic granules of cytotoxic lymphocytes that eliminate virus-infected and tumor cells
  • cleaved the microtubule network protein beta-tubulin after two distinct Arg residues, and potentially displays a unique function by cleaving its own specific substrates
  • may exert a critical role in NK cell-mediated tumor clearance
  • key component of T-killer (Tc) cells believed to mediate pro-apoptotic activities
  • extracellular GZMK is capable of activating F2R and inducing fibroblast cytokine secretion and proliferation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • hydrolyzes the nucleosome assembly protein SET in its recombinant and native forms or in intact cells
  • TP53 associates with granzyme K and is a physiological substrate of granzyme K (TP53 is as a cytotoxic bomb that can be triggered by granzyme K, leading to potentiating killing efficacy)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS