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FLASH GENE
Symbol ICAM2 contributors: - updated : 19-05-2006
HGNC name intercellular adhesion molecule 2
HGNC id 5345
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Endocrineparathyroid   highly
Lymphoid/Immunespleen   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connectivebone  highly
Epithelialbarrier/lining   
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Blood/Hematopoieticplatelet
Cardiovascularendothelial cell
Lymphoid/Immunelymphocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • a signal sequence, an extracellular region
  • two Ig-like domains
  • a single transmembrane (1TM) segment
  • a cytoplasmic C terminus containing a positively charged aminoacid cluster in the juxtamembrane cytoplasmic domain, ERM proteins binding
  • HOMOLOGY
    Homologene
    FAMILY
  • Ig superfamily
  • CATEGORY adhesion , signaling
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I transmembrane protein
    basic FUNCTION
  • redistributed by ezrin (VIL2) as a target for killer cells
  • activating PI3K pathway leading to inhibition of apoptosis
  • having a signaling function
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • ligand for (LFA1,CD11A/CD18)
  • binding and blocking ITGB2 dependent cell adhesion
  • interacting with ICAM1 and EZR in microvillar projections under phosphatidylinositol-4,5 biphosphate regulation
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS