Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SLC17A1 contributors: mct/ - updated : 19-01-2011
HGNC name solute carrier family 17 (sodium phosphate), member 1
HGNC id 10929
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
Urinarykidneytubuleconvoluted tubuleproximal tubule  Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • twelve putative transmembrane segments (12TM) with cytosolic N and C termini
  • a motif in the fourth TM domain charcacteristic of the ACS family
  • HOMOLOGY
    intraspecies paralog to SLC17A2, SLC17A3, SLC17A4
    Homologene
    FAMILY
  • major facilitator superfamily
  • sodium/anion cotransporter family
  • CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • phosphate transport protein, Na+ dependent
  • cotransporters in the apical membrane of renal proximal tubular cells play a major role in the maintenance of P(i) homeostasis
  • urate transporter, which mediates the transmembrane cotransport of Na+/Pi in oocytes
  • Cl&
  • 8722;-dependent polyspecific anion exporter involved in urate excretion under physiological conditions
  • polyspecific anion transporter with substrate specificity distinct from those of other SLC17 members
  • transports aspirin and salicylate, participating in the renal excretion of urate and nonsteroidal anti-inflammatory drugs
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to gout
    Variant & Polymorphism other
  • polymorphisms are associated with the development of gout
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS