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FLASH GENE
Symbol BMP5 contributors: - updated : 30-04-2007
HGNC name bone morphogenetic protein 5
HGNC id 1072
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver    
Reproductivefemale systembreastmammary gland highly
 female systemplacenta  highly
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo, fetal
Text developing skeletal structure limb bud,periosteum,perichondrium
RPE, choroid, trabecular meshwork
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
TGF-beta like domain, TGF-beta propeptide (LAP) like
isoforms Precursor cleaved at a consensus Arg-X-X-Argto yield C-ter mature domain
HOMOLOGY
interspecies homolog to murine short-ear (se)
homolog to Drosophila decapentaplegic-Vg,DVR family
intraspecies paralog to BMP6,BMP7
Homologene
FAMILY TGFB superfamily
CATEGORY signaling growth factor
SUBCELLULAR LOCALIZATION extracellular
text secreted
basic FUNCTION
  • modulating mesenchymal differentiation and inducing the processes of cartilage and bone formation
  • may play a role in the regeneration of periodontal tissue by promoting cell proliferation and protein expression
  • CELLULAR PROCESS cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    activated by cleaved by subtilisin-like convertases
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    in a syndrome of axial skeletal malformations and heterotopic ossification of the neck and back (ASMHO), analog to the short ear mouse
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    short ear mouse