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FLASH GENE
Symbol GHR contributors: mct - updated : 03-07-2013
HGNC name growth hormone receptor
HGNC id 4263
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestiveliver    
Urinarykidney    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • one fibronectin type III like domains
  • an UbE (ubiquitin-dependent endocytosis) motif
  • HOMOLOGY
    interspecies homolog to murine Ghr
    Homologene
    FAMILY cytokine family of receptors
    CATEGORY signaling hormone , receptor
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,nucleus
    text
  • type I membrane protein
  • extracellular domain of GHR (GHBP) is a circulating high affinity binding protein resulting from proteolysis of GHR and shedding of its extracellular domain
  • basic FUNCTION
  • receptor for pituitary gland growth hormone involved in regulating postnatal body growth
  • role of GHR gene polymorphisms in modulating adiposity and IGF1 activity in adolescents
  • role of muscle GHR signaling in facilitating cross-talk between muscle and other metabolic tissues
  • muscle GHR signaling regulates basal lipid oxidation, but not the induction of lipid oxidation in response to fasting
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling hormonal
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • BTRC is required for internalisation of the growth hormone receptor (GHR) and acts via a direct interaction with the ubiquitin-dependent endocytosis motif
  • CES1 is a novel transcriptional regulator of GHR gene expression, thereby establishing a unique nonenzymatic role for a carboxyesterase and expanding the potential biological roles of this protein superfamily
  • UBE2N and STUB1 are novel factors in the regulation of cell surface availability of GHR
  • BTRC interacts directly via its WD40 domain with the UbE (ubiquitin-dependent endocytosis) motif in GHR, promoting GHR ubiquitination
  • cell & other
    REGULATION
    Other GHR endocytosis occurs independently of GH and requires BTRC that is recruited to the UbE motif in the cytoplasmic tail and a downstream degron, DSGRTS, binding to BTRC
    GHR expression is regulated by free fatty acids (FFA)
    ASSOCIATED DISORDERS
    corresponding disease(s) GHIS1 , GHIS2
    Susceptibility to hypertension in female
    Variant & Polymorphism other GHRd3 genotype increasing the risk of hypertension among stroke patients, particularly females
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS