SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,mitochondria
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| intracellular,cytoplasm,cytosolic,vesicle
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| intracellular,cytoplasm,cytoskeleton,microtubule,mitotic spindle
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text
| translocated to plasma membrane through AP2 binding |
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synaptic vesicles |
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exists not only in cytosol but also in nuclei |
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TP53 co-localized with CLTC at the plasma membrane in response to EGF stimulation |
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is detected in lamellipodia in the absence of the adaptor and accessory proteins of endocytosis |
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localizes to the mitotic spindle |
basic FUNCTION
| involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules |
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functions as a vesicle transporter |
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nuclear form is required for the transactivation of TP53 target genes and plays a distinct role from clathrin-mediated endocytosis |
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play a role in receptor-mediated endocytosis |
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endogenous CLTCL1 and CLTC function independently in nonmuscle and muscle cells |
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functions as a built-in molecular brake that ensures a tight control of basal NFKB1 activation and gene expression in unstimulated cells |
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required for Golgi reassembly following disruption with pharmacological agents and for mitotic chromosome congression |
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involved in endocytosis, intracellular trafficking, and synaptic recycling |
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in addition to its classical role in membrane trafficking, brings the Scar/Wave complex to the plasma membrane, thereby controlling lamellipodium formation |
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has a well-characterized role in endocytosis and sorting at the trans-Golgi network and endosomes |
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plays likely a role in centrosome function that could directly or indirectly influence later mitotic events |
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does not play a direct role in centriole duplication but may affect centrosome number through another pathway |
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centrosome maturation requires CLTC and CLTCL1 influences the cell cycle independently, further establishing that functions of both clathrins are required for normal cell division |
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DNM2, CLTC and lipid rafts mediate SLC12A1 endocytosis and maintain steady-state apical surface SLC12A1 in native renal thick ascending limb (THAL) |
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plays a role in the processes of tumorigenesis and angiogenesis |
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SNX9 and clathrin heavy chain (CLTC) each have roles in mitosis during metaphase |
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SNX9 and CLTC function in the same molecular pathway for chromosome alignment and segregation, which is dependent on their direct association |
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CKAP5 is likely important in oocyte maturation and early embryo development, and CKAP5 might work together with CLTC in oocyte maturation |
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