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FLASH GENE
Symbol GZMA contributors: mct/npt - updated : 21-06-2017
HGNC name granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HGNC id 4708
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivepharynx   highly
Urinarykidney   moderately
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   predominantly
cell lineage
cell lines
fluid/secretion moderately in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 26 aa signal peptide
  • a peptidase S1 domain
  • conjugated GlycoP
    mono polymer homomer , dimer
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to rattus Gzma (70.5 pc)
    homolog to murine Gzma (68.9 pc)
    Homologene
    FAMILY
  • peptidase S1 family
  • granzyme subfamily
  • CATEGORY enzyme , immunity/defense
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,cytoplasm,cytosolic,granule
    intracellular,nucleus
    text
  • immunological synapse
  • basic FUNCTION
  • being necessary for target cell lysis in cell-mediated immune responses
  • producing cleavage after Lys or Arg
  • may be involved in apoptosis
  • acting as a lymphocyte tryptase
  • acting as a serine protease
  • critical role for GZMA and GZMB in dictating immunogenicity by influencing the mode of tumor cell death, indicating that granzymes contribute to the efficient generation of immune effector pathways in addition to their well-known role in apoptosis induction
  • CELLULAR PROCESS cell life, cell death/apoptosis
    protein, degradation
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • disulfide-linked homodimer
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS