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FLASH GENE
Symbol SRP19 contributors: np - updated : 21-03-2003
HGNC name signal recognition particle 19kDa
HGNC id 11300
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain    
Reproductivemale systemtestis   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES basic
STRUCTURE
motifs/domains
  • very basic C-terminal domain of seven lysine residues interrupted by two glycine residues
  • conjugated RiboP
    mono polymer heteromer , monomer , dimer
    HOMOLOGY
    interspecies homolog to C.elegans Y46G5A.19 and F09F7.2
    Homologene
    FAMILY SRP19 family
    CATEGORY RNA associated , signaling
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • mediating the targeting of secretory and membrane proteins to the rough endoplasmic reticulum membrane
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • subunit of the signal recognition particle (SRP) which is a ribonucleoprotein complex consisting of a7S molecule of 300 nucleotides and six proteins subunits (SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9)
  • INTERACTION
    DNA
    RNA binding to 7S RNA
    small molecule
    protein
  • binding to the 54 kDa subunit of the SRP,required for binding SRP54 to the S domain of 7S RNA
  • binding to SRPR
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS