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FLASH GENE
Symbol F12 contributors: mct/npt - updated : 15/09/2008
HGNC name coagulation factor XII (Hageman factor)
HGNC id 3530
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
 liver    
Respiratorylung    
cell lineage
cell lines
fluid/secretion serum
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a fibronectin type II domain
  • a fibronectin type I domain
  • two EGF-like domains
  • a cysteine-rich kringle domain,
  • a proline-rich domain
  • a serine protease (peptidase S1) domains
  • conjugated GlycoP
    isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to rattus F12 (73.5 pc)
    homolog to murine F12 (72.2 pc)
    Homologene
    FAMILY
  • peptidase S1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • serine protease, participating in the initiation of blood
  • coagulation, fibrinolysis, and the generation of bradykinin and angiotensin
    CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • cleaving prekellikrein
  • activating FVII, FXI
  • cell & other
    REGULATION
    activated by cleavage producing a heavy and a light (catalytic) chains
    Other positively regulated by estrogens
    ASSOCIATED DISORDERS
    corresponding disease(s) F12 , HAE3
    Susceptibility to shortening of the activated partial thromboplastin time (aPTT)
    Variant & Polymorphism SNP s2731672 increasing the risk of aPTT (Houlihan 2010)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS