basic FUNCTION
| plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation |
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KRT8/KRT18-coexpression plays a causal role in basement membrane invasion by transformed keratinocytes |
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KRT8/KRT18 intermediate filament (IF) contribution to the cell stiffness- extracellular matrix (ECM) rigidity interplay through a modulation of RHO-dependent actin organization and dynamics in simple epithelial cells |
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KRT8/KRT18 intermediate filaments constitute key promoters of the thymic epithelium integrity |
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Keratins 8/18 (KRT8/KRT18) are phosphoglycoproteins and form the major intermediate filament network of simple epithelia |
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have a dual role in retinal pigment epithelium (RPE) pathophysiology |
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KRT8/KRT18 expression could constitute a novel factor regulating primordial follicle death/survival, raising the possibility that alterations of KRT8/KRT18 expression could be involved in the accelerated depletion of the ovarian reserve leading to premature ovarian insufficiency |
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plays a direct role in the growth of Anaplastic thyroid carcinoma (ATC) |