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FLASH GENE
Symbol DBI contributors: mct/ - updated : 08-11-2006
HGNC name diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
HGNC id 2690
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   highly
Endocrineparathyroid   highly
Nervousbrain    
Reproductivemale systemprostate  highly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectivebone   
Muscularstriatumskeletal  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES Hydrophobic
STRUCTURE
motifs/domains
  • an hydrophobic binding site for acylCoA esters located within the second helical region
  • an ACBP domain
  • conjugated Other
    mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Dbi
    homolog to Drosophila tbh
    homolog to C.elegans H13N06.6
    Homologene
    FAMILY
  • ACBP family
  • CATEGORY regulatory , transport carrier
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • inducing medium-chain acyl-CoA ester synthesis
  • intracellular lipid-binding protein that transports acylCoA esters
  • displacing diazepan from the benzodiazepine (BZD) recognition sites located on the GABA type A receptor (acting as a neuropeptide to modulate the action of the GABA receptor)
  • downregulating the effects of GABA
  • involved in lipid metabolism and regulated by hormones and feeding status via transcription factors such as sterol regulatory element-binding protein 1 and peroxisome proliferator-activated receptor-gamma (PPARgamma)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS cellular trafficking transport
    text intracellular carrier of acyl-CoA esters
    PATHWAY
    metabolism lipid/lipoprotein
    signaling neurotransmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • target of (PPAR)gamma
  • sterol regulatory element-binding protein 1c (SREBP-1c) target gene in hepatocytes
  • cell & other
  • binding to medium and long-chain acylCoA esters
  • REGULATION
    induced by induced during adipocyte differentiation
    Other regulation by both sterol regulatory element-binding protein and peroxisome proliferator-activated receptor alpha in hepatocytes
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS