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FLASH GENE
Symbol APOB contributors: mct/ - updated : 03-05-2010
HGNC name apolipoprotein B (including Ag(x) antigen)
HGNC id 603
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunespleen   highly
Visualeyeanterior segmentcornea  
cell lineage
cell lines
fluid/secretion plasma
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
edited two forms B100 (liver), B48 (intestine) with:
  • proteoglycan binding site in the amino-terminal region
  • heparin-binding domain
  • LDL-receptor binding domain
  • conjugated GlycoP
    isoforms Precursor 4536 AA for the mature form APOB-100
    HOMOLOGY
    interspecies homolog to murine Apob (70.95 pc)
    homolog to rattus Apob (70.39 pc)
    Homologene
    FAMILY
    CATEGORY transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        intracellular
    intracellular,nuclear envelope
    text binding to nuclear matrix
    basic FUNCTION
  • conferring high level and position independent expression of ApoB, likely functioning as an insulator element
  • major protein component of very low density lipoprotein (VLDL) and low density lipoproteins, and is essential for the assembly and secretion of nascent VLDL particles
  • having no chromatin-modifying activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    involved in the cholesterol metabolism
    a component
  • major component of chylomicrons, VLDL, LDL
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • FAF2 and DERL1 bind with each other and with lipidated APOB and show colocalization around lipid droplets (LDs)
  • cell & other
    REGULATION
    Other post-translationnal palmitoylation
    DERL1 and FAF2 are engaged in dislocation and degradation of lipidated APOB at lipid droplets
    ASSOCIATED DISORDERS
    corresponding disease(s) FHBL1 , FDB
    Susceptibility myocardial infarction
    Variant & Polymorphism insertion/deletion in the signal peptide, which is a linkage marker for a gene conferring increased risk of type II diabetes
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS