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FLASH GENE
Symbol ADH1B contributors: mct/npt - updated : 30-06-2016
HGNC name alcohol dehydrogenase IB (class I), beta polypeptide
HGNC id 250
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • zinc-binding dehydrogenases
  • conjugated MetalloP
    mono polymer homomer , heteromer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • alcohol dehydrogenase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • alcohol dehydrogenase (class I), beta polypeptide, zinc dependent, plays a major role in ethanol catabolism
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism other
    signaling
    ethanol
    a component
  • homo- and heterodimers of alpha, beta, and gamma subunits
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • putative susceptibility factor for alcoholism
  • to esophageal squamous cell carcinoma (ESCC)
  • to genotoxicity induced by alcohol drinking
  • Variant & Polymorphism SNP , other
  • ADH1B*2 protective against alcoholism in Jewish and in Asian population and susceptibility in caucasians
  • ADHB allele 3 protective among African- Americans
  • SNP rs1229984, alcohol drinking, and smoking are independent risk factors for ESCC (Cui 2009)
  • associations between ADH1B/ALDH2 polymorphisms and genotoxicity in alcohol drinkers (Ishikawa 2007)
  • Candidate gene
    Marker
  • is a favorable prognostic factor for lung adenocarcinoma but an unfavorable prognostic factor for stomach adenocarcinoma
  • Therapy target
    ANIMAL & CELL MODELS