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FLASH GENE
Symbol AGA contributors: npt/ - updated : 13-10-2006
HGNC name aspartylglucosaminidase
HGNC id 318
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   moderately
Digestiveintestinesmall intestine   
 pancreas exocrine   highly
Lymphoid/Immunelymph node   moderately
Nervousbrain    
Reproductivefemale systemuteruscervix predominantly
 male systemtestis  moderately
Respiratorylung   moderately
Skin/Tegumentskin   highly
Urinarybladder   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
Connective    
Epithelialabsorptive excretorydigestive epithelium  
Epithelialbarrier/lininguroepithelium  
Epithelialsecretoryglandularexocrine 
Lymphoid    
cells
SystemCellPubmedSpeciesStageRna symbol
 fibroblast
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text amniotic fluid cells
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide of 23 AAs is removed in the ER, and then dimerization and glycosylation of the two precursor peptides occur (Saito 2008)
  • conjugated GlycoP
    mono polymer heteromer , tetramer
    isoforms Precursor inactive AGA precursor consisting of 346 amino acid residues on endoplasmic reticulum (ER)-bound ribosomes (Saito 2008)
    HOMOLOGY
    interspecies ortholog to murine Aga
    Homologene
    FAMILY
  • Ntn-hydrolase family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,endoplasmic reticulum ,rough,smooth
    intracellular,cytoplasm,organelle,Golgi
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,organelle,lysosome
    basic FUNCTION
  • involved in the catabolism of N-linked oligosaccharides of glycoproteins
  • cleaving asparagine from N-acetylglucosamines as one of the final steps in the lysosomal breakdown of glycoproteins
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism carbohydrate , other
    signaling
    catabolism of glycoproteins (protein deglycosylation)
    a component
  • heterotetramer of two alpha and two beta chains bound by disulfide bonds
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    Other targeted to the lysosome by M6P receptor mediated pathway
    ASSOCIATED DISORDERS
    corresponding disease(s) AGU
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS