SUBCELLULAR LOCALIZATION
| intracellular
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| intracellular,cytoplasm,organelle,mitochondria,outer
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,peroxisome
|
| intracellular,cytoplasm,cytosolic,microsome
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basic FUNCTION
| converting free long-chain fatty acids into fatty acyl-CoA ester |
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playing a role in lipid biosynthesis and fatty acid degradation |
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using preferentially palmitoleate, oleate and linoleate as substrate |
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play a role in facilitating long-chain fatty acid (LCFA) transport in mammalian cells under physiologic conditions |
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primary role in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance |
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essential for the synthesis of triacylglycerol |
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has a specific function in directing the metabolic partitioning of fatty acids toward beta-oxidation in adipocytes |
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required for oleate and linoleate mediated inhibition of cholesterol efflux through ABCA1 in macrophages |
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plays a critical role by promoting the inflammatory phenotype of macrophages associated with type 1 diabetes |
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catalyzes the thioesterification of fatty acids, and monocytes from humans with type 1 diabetes also exhibit increased ACSL1 |
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ACSL1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis |