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FLASH GENE
Symbol ACSL1 contributors: mct - updated : 23-04-2012
HGNC name acyl-CoA synthetase long-chain family member 1
HGNC id 3569
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   predominantly Homo sapiens
Endocrinepancreas   lowly
Nervousbrain   lowly
Respiratorylung   lowly
Urinarykidney   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoietic    
Connectiveadipose   
Epithelialsecretoryglandularendocrine 
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticerythroid
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta lowly
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
25-amino-acid consensus sequence,(FACs signature motif)
HOMOLOGY
interspecies homolog to C.elegans Y76A2B.3
Homologene
FAMILY
  • long-chain fatty-acid-coenzyme A ligase family
  • ATP-dependent AMP binding enzyme family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,organelle,mitochondria,outer
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,peroxisome
    intracellular,cytoplasm,cytosolic,microsome
    basic FUNCTION
  • converting free long-chain fatty acids into fatty acyl-CoA ester
  • playing a role in lipid biosynthesis and fatty acid degradation
  • using preferentially palmitoleate, oleate and linoleate as substrate
  • play a role in facilitating long-chain fatty acid (LCFA) transport in mammalian cells under physiologic conditions
  • primary role in adipocytes not in control of lipid influx, as previously considered, but in lipid efflux and fatty acid-induced insulin resistance
  • essential for the synthesis of triacylglycerol
  • has a specific function in directing the metabolic partitioning of fatty acids toward beta-oxidation in adipocytes
  • required for oleate and linoleate mediated inhibition of cholesterol efflux through ABCA1 in macrophages
  • plays a critical role by promoting the inflammatory phenotype of macrophages associated with type 1 diabetes
  • catalyzes the thioesterification of fatty acids, and monocytes from humans with type 1 diabetes also exhibit increased ACSL1
  • ACSL1 and gelsolin are oppositely regulated in adipogenesis and lipogenesis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism lipid/lipoprotein
    signaling
    lipid metabolism
    a component
  • CPT1A forms hetero-oligomeric complexes with ACSL1 and VDAC1 and is part of an outer membrane fatty acid transfer complex
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, cofactor, nucleotide,
  • magnesium Mg2+
  • AMP
  • protein
  • constitutive interaction between SLC27A1and ACSL1 contributes to the efficient cellular uptake of LCFAs in adipocytes through vectorial acylation
  • strong protein-protein interaction between CPT1A, ACSL1, and VDAC1
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS