basic FUNCTION
| regulates transcription in response to stress and growth factor stimuli |
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mediating the E1A responsiveness |
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acting as a tumor supressor gene in lung cancer |
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playing an important role in the mediation of cellular stress responses, development and transformation |
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having a suppressor activity in skin tumor formation |
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activates the transcription of apoptosis-related genes |
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may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals |
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transcription factor important for normal cellular development and survival |
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in cooperation with mutated oncogenes or tumor suppressor genes, can also elicit tumor suppressor function |
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may be a key regulator of the insulin promoter possibly stimulating activity in response to extracellular signals |
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importance of transcriptionally active ATF2 in melanoma development through fine-tuning of MITF expression ( |
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ATF2 was required for other endothelial cell outputs, such as cell migration and tubulogenesis |