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FLASH GENE
Symbol KRT6B contributors: npt/mct - updated : 08-06-2018
HGNC name keratin 6B
HGNC id 6444
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 mouthtongue  highly
 pharynx   highly
Respiratoryrespiratory tractlarynx  highly
Skin/Tegumentskinpalm   
 skinsole   
 skin appendagesnails   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Epithelialabsorptive excretorydigestive epithelium  
Epithelialsecretoryglandularexocrine 
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • conserved central rod domain, made of four helical domains (1A,1B,2A,2B) interrupted by non alpha helical linkers (L1,2,3)
  • the homology domains H1 and H2, variable region (V1,V2), end sequences (E1,E2)
  • mono polymer heteromer , dimer
    HOMOLOGY
    interspecies ortholog to murine Krt2-6b
    ortholog to C.elegans F58E10.3
    Homologene
    FAMILY
  • intermediate filament family
  • type II keratin family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,intermed filament
    text expressed with family members KRT16 and/or KRT17
    basic FUNCTION
  • required for filament assembly
  • CELLULAR PROCESS cell life, proliferation/growth
    cell organization/biogenesis
    PHYSIOLOGICAL PROCESS development
    text
  • cell shape and cell size control
  • ectoderm development
  • PATHWAY
    metabolism
    signaling
    a component
  • dimerizing with KRT17 and/or KRT16
  • heterodimer of a type I (acidic) and a type II (neutral to basic) keratin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) PC212
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS