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FLASH GENE
Symbol DRD5 contributors: mct - updated : 16-09-2015
HGNC name dopamine receptor D5
HGNC id 3026
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrainlimbic systemhippocampusdentate gyruspredominantly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Nervousneuron
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM)
  • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • dopamine receptor D5, high affinity, adenylate cyclase stimulating
  • mediates AGTR1 degradation via a ubiquitin-proteasome pathway
  • its activation ubiquitination of the glycosylated AT1R at the plasma membrane
  • dentate gyrus DRD1, but not DRD5, contribute to the formation of distinct contextual representations of novel environments
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling neurotransmission
    a component
  • complexing with GABA-A receptor complex through binding to DRD5 and promoting mutually inhibitory functional interactions between these receptor systems
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • crucial role for SNX1 in DRD5 trafficking and SNX1 depletion results in DRD5 dysfunction and thus may represent a novel mechanism for the pathogenesis of essential hypertension
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DTPC
    Susceptibility
  • to blepharospasm (OMIM 606798)
  • to attention deficit hyperactivity disorder (Adhd) with preferential transmission of paternal alleles
  • to schizophrenia, not bipolar disorder
  • Variant & Polymorphism repeat , other
  • allele 2 of dinucleotide repeat significantly associated with blepharospasm
  • variant in DRD5 may affect age at onset for ADHD
  • Candidate gene for primary cervical dystonia (allele 4 of (CT/GT/GA)n microsatellite is associated with cervical dystonia)
    Marker
    Therapy target
  • therapy for hypertension might be optimized by designing compounds that can target the AGTR1 and DRD5
  • ANIMAL & CELL MODELS