basic FUNCTION
| involved in vascular smooth muscle cell proliferation |
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may be regulating cell apoptosis and cell differentiation |
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regulating tumor angiogenesis |
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can directly bind to NRP1 on endothelial cells, and can promote the NRP1/KDR-mediated signaling pathway as well as NRP1-mediated biological activities |
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induces phosphatidylserine exposure independent of alterations in mitochondrial potential, caspase activation, or cell death |
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stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages |
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may be involved in chemoattraction at sites of inflammation and may contribute to disease processes such as atherosclerosis |
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inhibits retinal pigment epithelial cell attachment, spreading, and migration |
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mediate inflammation and involved in axonal regeneration in the oxidized form and in axonal degeneration in the reduced form |
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may be associated with the pathogenesis of spinal cord injury |
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plays an important role in mesenchymal stromal cells immunoregulatory functions, which are depending on cell environment |
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LGALS1 and CD69 are a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function |