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FLASH GENE
Symbol LGALS1 contributors: mct - updated : 03-01-2015
HGNC name lectin, galactoside-binding, soluble, 1
HGNC id 6561
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Lymphoid/Immunethymus    
Nervousnervecranial nerve  highly Homo sapiens
Skin/Tegumentskin   highly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivebone  highly Homo sapiens
Muscularstriatumcardiac  
Muscularstriatumskeletal  
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmature hematopoietic
Nervousastrocyte Homo sapiens
Nervousglia Homo sapiens
Nervousneuron
Skeletonosteoblast Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a single carbohydrate-recognition domain, recently identified as being overexpressed in tumor-associated capillary endothelial cells
  • mono polymer homomer , dimer
    HOMOLOGY
    Homologene
    FAMILY
  • galectin (galaptin/s-lectin) family
  • beta-galactoside-binding proteins family
  • CATEGORY adhesion , regulatory
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm
    intracellular,nucleus
    basic FUNCTION
  • involved in vascular smooth muscle cell proliferation
  • may be regulating cell apoptosis and cell differentiation
  • regulating tumor angiogenesis
  • can directly bind to NRP1 on endothelial cells, and can promote the NRP1/KDR-mediated signaling pathway as well as NRP1-mediated biological activities
  • induces phosphatidylserine exposure independent of alterations in mitochondrial potential, caspase activation, or cell death
  • stimulates monocyte migration in a dose-dependent manner but is not chemotactic for macrophages
  • may be involved in chemoattraction at sites of inflammation and may contribute to disease processes such as atherosclerosis
  • inhibits retinal pigment epithelial cell attachment, spreading, and migration
  • mediate inflammation and involved in axonal regeneration in the oxidized form and in axonal degeneration in the reduced form
  • may be associated with the pathogenesis of spinal cord injury
  • plays an important role in mesenchymal stromal cells immunoregulatory functions, which are depending on cell environment
  • LGALS1 and CD69 are a novel regulatory receptor-ligand pair that modulates Th17 effector cell differentiation and function
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to extracellular matrix proteins
  • binds LGALS3BP
  • selectively bound NRP1 via the carbohydrate-recognition domain, but did not bind FLT1, FLT4, KDR
  • is a novel ligand for MCAM and this interaction protects, in vitro, endothelial cells against apoptosis induced by LGALS1
  • prominent immunoregulatory function of LGALS1, is induction of apoptosis in activated T-cells by a process depending on the activity of SRC family tyrosine kinase, LCK
  • LGALS1 induces vascular permeability through the NRP1/FLT1 complex
  • interaction of LGALS1 and LGALS3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology
  • LGALS1, which encodes the galectin-1 protein, was a potential target of LYAR
  • cell & other
  • binding stronger to vascular smooth muscle cells
  • REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    in hepatocellular carcinoma involving methylation -sensitive complex formation at the transcriptional upstream and downstream elements
    tumoral     --over  
    in endothelial cells of different tumors
    tumoral     --over  
    in the tumor-associated endothelial cells of oral squamous cell carcinomas
    tumoral     --over  
    is a predictor of worse prognosis in pancreatic cancer patients
    Susceptibility
    Variant & Polymorphism
    Candidate gene target for angiostatic cancer therapy
    Marker
  • powerful diagnostic marker that distinguishes chondroblastic osteosarcomas from conventional chondrosarcomas
  • Therapy target
  • may serve as a potential diagnostic marker or therapeutic target for nasopharyngeal carcinoma
  • ANIMAL & CELL MODELS