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FLASH GENE
Symbol SOD3 contributors: mct - updated : 24-08-2017
HGNC name superoxide dismutase 3, extracellular
HGNC id 11181
EXPRESSION
Type widely
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   predominantly
Endocrinepancreas   predominantly
Nervousnerve   highly
Reproductivefemale systemovary  highly
Respiratorylung   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectiveadipose  highly
Epithelialsecretoryglandularendocrine 
Epithelialsecretoryglandularexocrine 
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text predominantly in placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an heparin-binding domain (HBD), important to restore vascular dysfunction produced by endotoxin
  • C-terminal region is involved in formation of the quaternary structure
  • mono polymer homomer , tetramer , octamer
    HOMOLOGY
    Homologene
    FAMILY superoxide dismutase (SOD) protein family
    CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    text a secreted protein found in the extracellular matrix of tissues (Takada 2009)
    basic FUNCTION
  • antioxidant enzymes that catalyze the dismutation of two superoxide radicals into hydrogen peroxide and oxygen
  • invoved in catabolic pathway of activated oxygen species, and free radical detoxification
  • may be protecting the brain, lungs, and other tissues from oxidative stress
  • tetrameric metalloenzyme responsible for the removal of superoxide anions from the extracellular space
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • forms a glycosylated homotetramer that is anchored to the extracellular matrix (ECM) and cell surfaces through an interaction with heparan sulfate proteoglycan and collagen
  • SOD3 octamer with high affinity may represent a way to influence the local concentration of EC-SOD to protect tissues specifically sensitive to oxidative damag
  • INTERACTION
    DNA
    RNA
    small molecule
    protein with fibulin 5 (interaction may represent a novel mechanism for controlling vascular redox state in the extracellular space in various cardiovascular diseases such as atherosclerosis and hypertension in which oxidative stress is increased)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in aortic dissection
    Susceptibility
  • to ischaemic heart disease
  • to insulin resistance and the susceptibility to type 2 diabetes
  • Variant & Polymorphism other predisposing carriers to ischaemic heart disease
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS