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FLASH GENE
Symbol ANXA3 contributors: mct - updated : 06-02-2008
HGNC name annexin A3
HGNC id 541
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestivesalivary gland   highly
Hearing/Equilibriumear   highly
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus
  • a C terminal "core" region with four repeats homolog to the endonexin fold
  • HOMOLOGY
    interspecies homolog to murine Anxa3
    homolog to C.elegans ZC155.1
    Homologene
    FAMILY
  • annexin family
  • calcium-dependent phospholipid-binding protein family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • placental anticoagulant protein III
  • playing a role in the regulation of cellular growth and in signal transduction
  • inhibiting the phosphalipase A2
  • cleaving of inositol 1,2-cyclic phosphate to form inositol 1-phosphate (1,2-cyclic-inositol-phosphate phosphodiesterase)
  • inducing migration and tube formation of umbilical vein endothelial cells
  • angiogenic factor that induces VEGF production through the HIF-1 pathway
  • involved in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate
  • may also play a role in anti-coagulation
  • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS coagulation/hemostasis
    PATHWAY
    metabolism purine/pyrimidine
    signaling signal transduction
    inositol phosphate metabolism
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • calcium Ca2+
  • phospholipid
  • protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS