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FLASH GENE
Symbol DRD3 contributors: mct/npt - updated : 25-03-2013
HGNC name dopamine receptor D3
HGNC id 3024
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbraindiencephalonhypothalamusnucleus accumbens 
Reproductivemale systemtestis   
Visualeye    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Drd3
    homolog to C.elegans C09B7.1
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
  • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
    text both DRD3 and GRK4 co-localize in lipid rafts of human renal proximal tubule cells (Villar 2009)
    basic FUNCTION
  • inhibiting adenylyl cyclase through inhibiory G protein
  • playing a role in cognitive and emotional functions
  • exhibits a tolerance property where in the magnitude of the second agonist-induced response is reduced compared to the first response and progressively decreases upon repeated agonist application (Kuzhikandathil 2004)
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS behavioral
    PATHWAY
    metabolism
    signaling neurotransmission
    synaptic transmission
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between DRD3 and GRK4 (Villar 2009)
  • DRD3 interaction with GNA12/GNA13 that increases sodium excretion may have a role in the regulation of blood pressure
  • cell & other
    REGULATION
    Other target for drugs treating schizophrenia and Parkinson disease
    regulated by brain derived neurotrophic factor (BDNF)
    ASSOCIATED DISORDERS
    corresponding disease(s) ETM1
    Susceptibility
  • to schizophrenia
  • to essential tremor
  • to autism spectrum disorder
  • Variant & Polymorphism SNP , other
  • association between Ser9Gly and risk of essntial tremor not confrmed (Lorenz 2008)
  • common protective haplotype against schizophrenia (Costas 2009)
  • association between SNP rs167771 located in the DRD3 gene was found in autism spectrum disorder (de Krom 2009)
  • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
    DRD3-deficient mice (Accili, 1996)