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FLASH GENE
Symbol CD80 contributors: mct - updated : 13-02-2015
HGNC name CD80 antigen (CD28 antigen ligand 1, B7-1 antigen)
HGNC id 1700
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node    
 tonsils    
Reproductivefemale systembreastmammary gland  
Respiratorylung    
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / Hematopoieticbone marrow   
cells
SystemCellPubmedSpeciesStageRna symbol
Blood/Hematopoieticmonocyte
Lymphoid/ImmuneB cell
Lymphoid/Immunedendritic cell
Lymphoid/Immunelymphocyte
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • Ig variable-like (IgV) domains, Ig constant-like (IgC) domains and intracellular domains
  • a transmembrane domain (1TM)
  • a cytoplasmic domain, component of a costimulatory signal with B7-2 (CD86) and CD28
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Cd80
    Homologene
    FAMILY Ig superfamily, k1 B box family, B7 family
    CATEGORY antigen
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 1
    basic FUNCTION
  • involved in the costimulatory signal essential for t lymphocytes activation
  • T cell proliferation and cytokine production
  • playing a role in stimulating T lymphocyte activation
  • direct signaling through CD86/CD80 is a potent regulator of IgG secretion by previously activated B cells
  • CD80/CD86 engagement results in DC production of the pro-inflammatory cytokine IL6, which is necessary for full T cell activation
  • distinct but complementary roles of CD80 and CD86 IgV and IgC domains in T cell activation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD28, CD86 ligand
  • SPI1 is a critical factor for the expression of CD80 and CD86
  • interaction of CD86, CD80 with appropriate receptors is essential for an effective T cell response
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --other  
    inadequate expression during early oral squamous carcinoma formation may contribute to the escape of tumors from immune elimination
    Susceptibility
  • putative susceptibility gene for rheumatoid arthritis
  • Systemic lupus erythematosus (SLE)
  • Variant & Polymorphism other genetic variants increasing the risk of Systemic lupus erythematosus (SLE)
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS