basic FUNCTION
| LEUTX arose on the primate lineage |
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may have originated by tandem duplication from the CRX gene in the Otx gene family, or from the mammalian TPRX1 gene which itself may have originated from CRX |
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ARGFX, TPRX1 LEUTX, DPRX genes arose by asymmetric evolution from the CRX homeobox gene at the base of eutherian evolution, as part of a dynamic series of duplications |
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partial overlap of function between LEUTX and TPRX1 |
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ETCHbox (Eutherian Totipotent Cell Homeobox) gene |
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ARGFX, LEUTX and TPRX1 regulate a set of developmentally-important genes precisely modulated at the time when the earliest cell fate decisions are made |
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paired (PRD)-like homeobox gene that is expressed almost exclusively in human embryos during preimplantation development |
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acts as a TAATCC-targeting transcriptional activator, like other K50-type PAIRED-LIKE transcription factors (TF) |
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functions as a transcriptional activator important for human embryogenesis |