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FLASH GENE
Symbol KPNA7 contributors: mct - updated : 23-10-2018
HGNC name karyopherin subunit alpha 7
HGNC id 21839
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to KPNA2
Homologene
FAMILY karyopherin alpha nuclear importer family
CATEGORY tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
text
  • predominantly nuclear distribution under steady state conditions
  • basic FUNCTION
  • nuclear import proteins that recognize and bind nuclear localization signals (NLSs) in proteins to be transported to the nucleus
  • functional role for KPNA7 in human cancer
  • contribution of KPNA7 to the regulation of cancer cell growth and the maintenance of nuclear envelope environment
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • could be specialized for interactions with select NLS-containing proteins, potentially impacting developmental regulation
  • KPNA7 interaction was confirmed for MVP and ZNF414, with distinct roles as novel regulators of pancreatic cancer cell growth
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) SICACCH
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in a subset of pancreatic cancer cell lines and acts as a critical regulator of growth in these cells
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS