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FLASH GENE
Symbol SPINDOC contributors: mct - updated : 09-03-2018
HGNC name spindlin interactor and repressor of chromatin binding
HGNC id 25115
EXPRESSION
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY DNA associated
SUBCELLULAR LOCALIZATION
basic FUNCTION
  • SPINDOC associates with TCF4 in a SPIN1-dependent manner and dampens SPIN1 coactivator activity
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • SPINDOC directly binds SPIN1 and strongly disrupts its histone methylation reading ability, causing it to disassociate from chromatin
  • SPIN2A, 2B, 3, and 4, also bind SPINDOC
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS