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FLASH GENE
Symbol PPP1R3C contributors: mct - updated : 30-05-2016
HGNC name protein phosphatase 1 regulatory subunit 3C
HGNC id 9293
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • modulates glycogen metabolism, particularly glycogen synthesis
  • may play a critical role in cancer cell growth in association with glucose levels
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • HIF1A promotes glycogen accumulation through regulating PPP1R3C expression under hypoxia, which revealed a novel metabolic adaptation of cells to hypoxia
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    significantly hypermethylated in Colorectal cancer tissues and colon cancer cell lines
    Susceptibility
  • to a milder phenotype in Lafora disease
  • Variant & Polymorphism other
  • a PPP1R3C variant contributes to a milder phenotype in Lafora disease
  • Candidate gene
    Marker
  • PPP1R3C methylation or its combined use of EFHD1 methylation was highly positive in colorectal cancer (CRC) plasma samples, and they might be useful in detection of CRC, especially for early-stage CRCs
  • Therapy target
    ANIMAL & CELL MODELS