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FLASH GENE
Symbol ESRP1 contributors: mct - updated : 29-03-2023
HGNC name epithelial splicing regulatory protein 1
HGNC id 25966
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
intraspecies paralog to ESRP2
Homologene
FAMILY
CATEGORY regulatory
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleoplasm,nuclear bodies
basic FUNCTION
  • ESRP1 and ESRP2 are coordinators of an epithelial cell-type-specific splicing program
  • ESRP1 and ESRP2 are cell-type-specific regulators of transcripts that switch splicing during the epithelial-mesenchymal transition (EMT)
  • could be a master regulator of the EMT process in pituitary adenomas causing acromegaly
  • could play an important role in the morphological changes underlying embryogenesis of the placenta and embryo
  • ESRP1 and PNN modulate alternative splicing of a specific subset of target genes, but not general splicing events, in corneal cells to maintain or enhance epithelial characteristics
  • may function prominently as a master regulator of the EMT process in pituitary adenomas causing acromegaly
  • ESRP1 and ESRP2 regulate alternative splicing events associated with epithelial phenotypes of cells, and both are down-regulated during the epithelial-mesenchymal transition
  • ESRP1 and HNRNPM are splicing regulators that promote an epithelial splicing program and a mesenchymal splicing program, respectively
  • ESRP1 and ESRP2 control the epithelial-to-mesenchymal transition (EMT) splicing program in cancer
  • novel role for ESRP1 that could form the basis for the prevention of tamoxifen resistance in ER+ breast cancer
  • likely important role for ESRP1 in regulating trophoblast migration and invasion during placentation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • complex modes of interaction between HNRNPM and ESRP1 in regulation of splicing in disease-relevant contexts
  • ablation of ESRP1 and ESRP2 impairs epithelial tight junction (TJ) integrity through loss of the epithelial isoform of Rho GTP exchange factor ARHGEF11
  • LRRFIP2 is regulated by epithelial splicing regulatory protein 1 (ESRP1) and this is correlated with metastatic potential of gastric cancer cells
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) DFNB109
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    of ESRP1 and ESRP2 is thus closely associated with a motile phenotype of cancer cells
    tumoral     --over  
    was associated with longer survival in comparison with low ESRP1 expression in pancreatic carcinoma (
    tumoral     --over  
    associated with poor prognosis in estrogen receptor positive (ER+) breast tumors
    tumoral     --over  
    in the early stage, and gradually decreases with the increasing colorectal cancer stage, wherein epithelial cell to mesenchymal cell transition (EMT) occurs during cancer progression
    tumoral     --over  
    in primary prostate cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancerendocrinepancreas
    devising mechanisms to upregulate ESRP1 may exert a beneficial therapeutic effect in PDAC
    cancerdigestivecolon
    therapeutic target in colon cancer
    ANIMAL & CELL MODELS