Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol CIR1 contributors: mct - updated : 02-07-2014
HGNC name corepressor interacting with RBPJ, 1
HGNC id 24217
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a basic lysine and acidic serine-rich (BA) domain
  • a zinc knuckle-like motif
  • arginine/serine dipeptide repeat (RS) domain in its C terminal region
  • HOMOLOGY
    Homologene
    FAMILY family of SR-related proteins
    CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus,nucleoplasm,nuclear bodies,nuclear speckles
    text
  • colocalized with SRSF2 and RP9 in nuclear speckles
  • basic FUNCTION
  • act as a transcriptional corepressor
  • plays a role in splicing regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • RP9 binding protein
  • interact with U2AF1 through the BA domain, with SRSF2 and SF2/ASF through the RS domain, and with RP9 outside the BA domain
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS