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FLASH GENE
Symbol LRRC55 contributors: mct - updated : 06-02-2013
HGNC name leucine rich repeat containing 55
HGNC id 32324
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Nervousbrain     Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • N-terminal signal peptide resulting in extracellular localization of the LRR domain
  • a short cytoplasmic C-terminal tail containing a short stretch of acidic residues
  • HOMOLOGY
    intraspecies paralog to LRRC52, LRRC26, LRRC38
    Homologene
    FAMILY
    CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • LRRC52, LRRC55, and LRRC38 potentially function as LRRC26-type auxiliary subunits of BK channels
  • LRRC26 and its paralogs are structurally and functionally distinct from the beta-subunits and are a gamma family of the BK channel auxiliary proteins, which potentially regulate the channel gating properties over a spectrum of different tissues or cell types
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • belongs to an extracellular leucine-rich-repeat–only (Elron) cluster, which includes five other LRRC proteins: LRRC38, LRRC52, LRRC55, LRTM1 and LRTM2
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS