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FLASH GENE
Symbol ZNF692 contributors: mct - updated : 05-11-2012
HGNC name zinc finger protein 692
HGNC id 26049
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveliver   highly Mus musculus
Nervousbrain   highly Mus musculus
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY transcription factor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus
basic FUNCTION
  • represses gene expression of the phosphoenolpyruvate carboxykinase (PCK2), a key enzyme of gluconeogenesis
  • novel key modulator of PCK2 gene expression regulated by AMPK
  • key modulator of hepatic glucose production regulated by AMPK
  • mediator of transcriptional repression of gluconeogenic genes in response to ATIC
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binds to the promoter element of PCK2, a key enzyme of gluconeogenesis
  • cell & other
    REGULATION
    Phosphorylated by at Ser(470) by AMPK, and phosphorylation reduces its DNA-binding activity
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    diabete  
    combination of the diabetes therapies, pharmacological or nutraceutical induction of ZNF692 gene expression would be expected to reduce blood glucose levels in patients with diabetes
    ANIMAL & CELL MODELS
  • AREBP mice had lower blood glucose levels than WT mice after injection of Atic