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FLASH GENE
Symbol HOTS contributors: mct - updated : 24-10-2012
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon highly Homo sapiens
Nervousbrain   highly Homo sapiens
Urinarykidney   highly Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularsmooth  highly Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
IMPRINTING paternally
text maternally expressed
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
HOMOLOGY
Homologene
FAMILY
CATEGORY RNA associated , tumor suppressor
SUBCELLULAR LOCALIZATION     intracellular
intracellular,nucleus,nucleolus
text
  • localizes to the nucleus and nucleolus
  • basic FUNCTION
  • primate-conserved, ubiquitous transcript antisense to H19
  • polysome-associated RNA encoding a nucleolar protein
  • may mediate its tumor suppressor activity by targeting DNA replication and cell cycle regulation
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacts with the enhancer of rudimentary homolog (ERH) protein
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    inhibits Wilms, rhabdoid, rhabdomyosarcoma, and choriocarcinoma tumor cell growth
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS