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FLASH GENE
Symbol ANXA5 contributors: mct - updated : 02-04-2007
HGNC name annexin A5
HGNC id 543
EXPRESSION
Type widely
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   highly
Digestiveliver   predominantly
Nervousbrain   highly
Reproductivefemale systemplacenta  predominantly
Respiratorylung   highly
Urinarykidney   predominantly
Visualeyeanterior segmentcornea  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connectivecartilage   
cells
SystemCellPubmedSpeciesStageRna symbol
 chondrocyte
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a relatively short N terminus and a C terminal "core" region
  • four repeats homolog to the endonexin fold
  • mono polymer monomer
    HOMOLOGY
    interspecies homolog to murine Anxa5
    homolog to C.elegans Zc155?1
    Homologene
    FAMILY
  • annexin family and lipocortin family
  • chordate annexin family
  • CATEGORY regulatory , transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    basic FUNCTION
  • implicated in membrane-related events along exocytotic and endocytotic pathway
  • phospholipase A2 and protein kinase C inhibitory protein with Ca2+ channel activity
  • potential role in cellular signal transduction, inflammation, growth and differentiation
  • functioning as an inhibitor of coagulation owing to its ability to bind to anionic phospholipids exposed on the surface of platelets, thereby inhibiting aggregation
  • through an inducible association with IFNGR2, modulates cellular responses to IFN-gamma by modulating signaling through the Jak-Stat1 pathway
  • CELLULAR PROCESS cell life, differentiation
    cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS exocytosis transport , endocytosis transport
    text anticoagulation activity
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • component of chondrocytes anchorin CII collagen receptor
  • INTERACTION
    DNA
    RNA
    small molecule metal binding, other,
  • Ca2+
  • phospholipid
  • protein ATRX
    cell & other
    REGULATION
    inhibited by downregulated in adult articular cartilage
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    could be responsible for immunological and hemostatic phenomena that, together, lead to fetal loss
    Susceptibility to recurrent pregnancy loss
    Variant & Polymorphism M2 promoter haplotype is a risk factor for recurrent pregnancy loss in German females
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS