basic FUNCTION
| role in the maintenance of the G2/M checkpoint following UV irradiation, and in the cellular UV response |
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required for the activation of extracellular signal-regulated kinase 1/2 (ERK1/2) signaling upon UV irradiation but not in response to mitogens, such as epidermal growth factor stimulation |
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plays a role in maintenance of the G2/M checkpoint following UV irradiation |
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NEK2, NEK6, NEK7 and NEK9 contribute to the establishment of the microtubule-based mitotic spindle, whereas NEK1, NEK10 and NEK11 have been implicated in the DNA damage response |
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NEK10 is essential for ciliogenesis in mammals |
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NEK10 may be involved in the control of mtDNA content |