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FLASH GENE
Symbol TBC1D15 contributors: mct - updated : 25-08-2011
HGNC name TBC1 domain family, member 15
HGNC id 25694
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY Ypt/Rab-GAP, TBC domain family
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
text localized predominantly to the cytosol
basic FUNCTION
  • potentially involved in RAB7A-mediated late endosomal trafficking
  • TBC1D15 and and VPS39 regulate lysosomal morphology and play a role in maintaining growth factor dependence
  • mitochondrial Rab GTPase-activating protein (Rab-GAP), governs autophagosome biogenesis and morphology downstream of Parkin activation
  • TBC1D15 and TBC1D17 mediate proper autophagic encapsulation of mitochondria by regulating RAB7A activity at the interface between mitochondria and isolation membranes
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • TBC1D17, also participates in mitophagy and forms homodimers and heterodimers with TBC1D15
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS