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FLASH GENE
Symbol TMEM88 contributors: mct - updated : 04-07-2011
HGNC name transmembrane protein 88
HGNC id 32371
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately Homo sapiens
Lymphoid/Immunespleen   moderately Homo sapiens
Reproductivefemale systemplacenta  highly Homo sapiens
Urinarykidney   moderately Homo sapiens
Visualeye   moderately Homo sapiens
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Muscularstriatumcardiac moderately Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two-transmembrane domains (AAs 44–66 comprise the first transmembrane domain, and AAs 86–108 comprise the second)
  • C-terminal VWV (Val-Trp-Val) motif is sufficient to recognize the Dvl PDZ domain
  • HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may plays a role in regulating Wnt signaling
  • blocks Wnt signaling, presumably by disrupting the Dvl-Fz interaction in cells
  • conditionally modulates Wnt signaling-related gene expression
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interaction between the PDZ domain of Dvl and the C-terminal tail of TMEM88
  • associates with Dvl proteins and regulates Wnt signaling in a context-dependent manner
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS