basic FUNCTION
| potentially bridges BCR-associated kinases to the PI3K pathway by regulating PI3K localization |
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cytosolic adaptor that can recruit the PI3K p85 subunit when tyrosine-phosphorylated on three YXXM motifs by the tyrosine kinase SYk |
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essential in the maintenance of mature B cells through functional coupling with REL |
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in B lymphocytes, facilitates signaling from the antigen receptor |
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functions in B and NK cells to bind and activate PI3K, leading to AKT1 phosphorylation |
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PIK3AP1 and CD19 have complementary roles in BCR-mediated PI3K activation, thereby, at least in part, contributing to B-cell development |
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acts as a negative regulator of the host defense system against bacterial and viral infections via all TLR groups |
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essential activator of the PI3K pathway downstream of TLR signaling, providing a brake to limit potentially pathogenic excessive TLR responses |
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critical link between TLR ligation and PI3K activation in macrophages |
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is a unique TIR domain-containing TLR signaling adapter crucial for linking TLRs to PI3K activation and regulating the inflammatory response |
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unique TIR-domain containing adapter molecule that forms a critical link between TLRs and activation of PI3K |
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inhibits proliferation and differentiation of myeloid progenitors in the steady state and during demand situations |
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is a critical link between IL1R1 and the metabolic status of activated T cells that ultimately regulates the differentiation of inflammatory Th17 cells |
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role for PIK3AP1 in promoting TLR-induced IFNA production in plasmacytoid dendritic cells (pDC) and in systemic lupus erythematosus pathogenesis |
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is a multimodular, multifunctional signal transducer that regulates signal transduction pathways in leukocytes, including macrophages, B-cells, and T-cells |
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is a complex hub that processes signals from multiple pathways in diverse cell types of the immune system |