Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol MPHOSPH8 contributors: mct - updated : 28-01-2011
HGNC name M-phase phosphoprotein 8
HGNC id 29810
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a chromodomain that is a methyl-H3K9-binding motif near the N-terminal
  • four copies of ankyrin-repeats near the C-terminal
  • conjugated PhosphoP
    HOMOLOGY
    Homologene
    FAMILY
    CATEGORY regulatory
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • encoded genuine M phase phosphoproteins
  • methyl-H3K9-binding protein which contributes to tumour progression
  • recognizes methyl-H3K9 marks and directs DNA methylation to repress tumour suppressor gene expression and, in turn, has an important function in epithelial-to-mesenchymal transition and metastasis
  • couples histone H3K9 methylation and DNA methylation for tumour suppressor gene silencing and metastasis
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • targets the E-cadherin (CDH1) gene promoter and modulates the expression of this key regulator of cell behaviour and tumour progression through its methyl-H3K9 binding
  • could repress E-cadherin expression through methyl-H3K9 binding
  • interacts with H3K9 methyltransferases EHMT1 and SETDB2 , as well as DNA methyltransferase 3A
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS