basic FUNCTION
| play a role in the DNA methylation |
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acts as a transcription factor located in the nucleus |
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TET3-mediated DNA hydroxylation is potentially involved in epigenetic reprogramming of the zygotic paternal DNA following natural fertilization |
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in the nucleus, TET3 depolymerizes from KPNA2,and KPNB1, and fulfills its function as a transcription factor or dioxygenase |
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novel function of TET3 that likely supports the function of OGT |
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TET2, TET3 are required for 5-hydroxymethylcytosine (5hmC) enrichment at enhancers, a condition necessary for expression of adjacent genes |
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respective functions of TET3 and DNA replication in paternal DNA demethylation and unexpected contribution of TET3 to demethylation of the maternal genome |
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TeT3 serves as a synaptic activity sensor to epigenetically regulate fundamental properties and meta-plasticity of neurons via active DNA demethylation |
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maternal TET3 is dispensable for embryonic development but is required for neonatal growth |
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negatively regulates type I IFN production independent of DNA demethylation |
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TET3, a DNA dioxygenase, can rapidly and efficiently convert fibroblasts directly into functional neurons |
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TET1, TET2, TET3 influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling |
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distinct roles for TET2 and TET3 in human erythropoiesis |
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overexpression of TET3 in donor cells enhances goat somatic cell nuclear transfer efficiency |
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non-catalytic action of TET3 is essentially required for the maintenance of the neural stem cell (NSC) pool in the adult subventricular zone (SVZ) niche by preventing premature differentiation of NSCs into non-neurogenic astrocyte |
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TET2 and TET3 are guardians of Treg cell stability and immune homeostasis |
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CDK5-mediated phosphorylation of TET3 is required for robust activation of neuronal differentiation program |
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is a methylcytosine dioxygenase that initiates DNA demethylation during early zygote formation, embryogenesis, and neuronal differentiation and is intolerant to haploinsufficiency |
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plays an important role in rapidly demethylating the paternal genome after fertilization |
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important role of TET3 in early embryonic development and neuronal function |
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TET3 plays a key role in actively reversing DNA methylation during development |