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FLASH GENE
Symbol SPATA24 contributors: mct - updated : 08-12-2010
HGNC name spermatogenesis associated 24
HGNC id 27322
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  highly Homo sapiens
cells
SystemCellPubmedSpeciesStageRna symbol
Reproductivespermatid Homo sapiens
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY motor/contractile
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm
intracellular,nucleus,nucleoplasm
intracellular,nucleus,chromatin/chromosome
intracellular,nucleus,nucleolus
text
  • expressed mainly in the cytoplasm of spermatids
  • in cyto- and nucleoplasma, and enriched in the nucleolus
  • with Geminin, were detected in the chromatin near TBP/TBPL1 binding sites
  • basic FUNCTION
  • may play a role in cytoplasm movement and removal during spermiogenesis
  • could contribute to the precise timing of the molecular events in male germ cells, specifically by linking transcription to chromatin remodeling in round spermatids
  • synergizes with geminin and TBP in the activation of TATA box-containing promoters, and with TBPL1 and geminin in the activation of the TATA-less NF1 promoter
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • TBPL1 interacting protein in testis
  • interacts also with CBX5 proteins, thereby establishing an intriguing link between transcription and chromatin condensation
  • strong binding partner of Geminin (GMNN)
  • also interacts with several polycomb factors, with the general transcription factor TBP (TATA box binding protein), and with the related protein TBPL1 (TRF2)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS