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FLASH GENE
Symbol ULK3 contributors: mct - updated : 16-02-2011
HGNC name unc-51-like kinase 3 (C. elegans)
HGNC id 19703
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveliver   highly
 stomach   lowly
Endocrineadrenal gland   moderately
Lymphoid/Immunethymus   lowly
Nervousbrain   highly
Reproductivefemale systemplacenta  lowly
 male systemtestis  moderately
 male systemprostate  lowly
Respiratorylung   lowly
Urinarykidney   highly
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period fetal, pregnancy
Text highly in brain, placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • two MIT domains
  • one protein kinase domain
  • conjugated PhosphoP
    HOMOLOGY
    interspecies homolog to murine Ulk3 (94.1pc)
    homolog to rattus Ulk3 (94.6pc)
    Homologene
    FAMILY
  • protein kinase superfamily
  • Ser/Thr protein kinase family
  • APG1/unc-51/ULK1 subfamily
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • protein serine/threonine kinase activity
  • able to regulate GLI proteins positively in a kinase activity-dependent manner
  • involved in the SHH pathway as a positive regulator of GLI proteins
  • phosphorylation of GLI1 by ULK3 results in GLI1 nuclear accumaltion
  • participates in the transduction of the SHH signal also independently of its kinase activity
  • a potential dual function in the SHH signal transduction pathway and an additional way of regulating GLI proteins by SUFU, through binding to and suppression of ULK3
  • able to enhance the activity of GLI1 and GLI2 proteins in a kinase activity-dependent manner
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
  • ATP binding
  • protein
  • through its kinase domain interacts with Suppressor of Fused (SUFU), a protein required for negative regulation of Gli proteins
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    induces autophagy and senescence
    Susceptibility
    Variant & Polymorphism SNP SNp is associated with blood pressure and/or hypertension in the Japanese
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS