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FLASH GENE
Symbol KDM7A contributors: shn/mct - updated : 22-02-2017
HGNC name lysine demethylase 7A
HGNC id 22224
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine  moderately
 liver   moderately
Lymphoid/Immunespleen   lowly
Nervousbrainhindbraincerebellum predominantly
Reproductivemale systemseminal vesicles  moderately
Respiratorylung   lowly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a JmjC domain
  • 1 PHD-type zinc finger
  • a predicted Fe(II)- and a alpha-ketoglutarate (-KG)-binding sites
  • HOMOLOGY
    interspecies ortholog to LOC321248, Danio rerio
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JmjC domain-containing proteins subfamily
  • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    intracellular,nucleus,nucleolus
    basic FUNCTION
  • as a novel histone demethylase specific for these two repressing marks
  • might contribute to transcriptional regulation of genes in the nervous system
  • might regulate the proliferation or differentiation of neurons and plays an important role in brain development
  • ability to mediate the direct removal of methyl groups from H3K9me2/me1 and H3K27me2/me1
  • co-activator function having important functional roles in neuronal development
  • modifies the level of methylation in histone and participates in epigenetic gene regulation
  • plays a tumor-suppressive role by regulating angiogenesis
  • KDM7A regulates ICAM1 protein stability via a lysosome-dependent pathway
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text histone demethylase activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
  • regulates transcription and H3K9me2 and H3K27me2 levels of the follistatin gene
  • small molecule
    protein
  • pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation
  • KDM6B and KDM7A play a role in localizing elongation factors SUPT6H and SUPT16H to the target genes
  • EHMT2 orchestrates PHF19 and KDM7A to promote histone H3K27 methylation
  • role of KDM7A in ICAM1 protein stabilization
  • mediates TNF-induced ICAM1 protein upregulation mediated by induction of KDM7A, which regulates the TFEB-mediated lysosomal activity
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --over  
    transcript levels were positively correlated with disease activity in systemic lupus erythematosus
    constitutional     --over  
    accelerated neural differentiation
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cancer  
    increased KDM7A expression suppressed tumor growth by down-regulating angiogenesis under nutrient starvation
    ANIMAL & CELL MODELS
  • splicing-blocking antisense morpholino oligonucleotides that targeting Zebrafish KDM7 ortholog lead to a curly tail and marked decrease in size of the tectum with loss of neurons
  • depletion of KDM7 by RNAi in primary cultured mouse neurons also resulted in down-regulation of follistatin mRNA