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FLASH GENE
Symbol JHDM1D contributors: shn - updated : 04-07-2010
HGNC name jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)
HGNC id 22224
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   lowly
Digestiveintestinesmall intestine  moderately
 liver   moderately
Lymphoid/Immunespleen   lowly
Nervousbrainhindbraincerebellum predominantly
Reproductivemale systemseminal vesicles  moderately
Respiratorylung   lowly
Urinarykidney   moderately
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a JmjC domain
  • 1 PHD-type zinc finger
  • a predicted Fe(II)- and a alpha-ketoglutarate (á-KG)-binding sites
    • HOMOLOGY
    interspecies ortholog to LOC321248, Danio rerio
    Homologene
    FAMILY
  • JHDM1 histone demethylase family
  • JmjC domain-containing proteins subfamily
    • CATEGORY transcription factor
    SUBCELLULAR LOCALIZATION
    basic FUNCTION
  • might contribute to transcriptional regulation of genes in the nervous system
  • might regulate the proliferation or differentiation of neurons and plays an important role in brain development
  • ability to mediate the direct removal of methyl groups from H3K9me2/me1 and H3K27me2/me1
  • co-activator function having important functional roles in neuronal development
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS development , nervous system
    text histone demethylase activity
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
  • regulates transcription and H3K9me2 and H3K27me2 levels of the follistatin gene
    • small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • splicing-blocking antisense morpholino oligonucleotides that targeting Zebrafish KDM7 ortholog lead to a curly tail and marked decrease in size of the tectum with loss of neurons
  • depletion of KDM7 by RNAi in primary cultured mouse neurons also resulted in down-regulation of follistatin mRNA